SCHEMBL29036747

SCHEMBL29036747

C#CC(C)(O[SiH2]OC(C)(C#C)c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.40
ALDH1A1 P00352 2/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.34
TAAR1 Q96RJ0 1/20 0.33
ESR1 P03372 2/20 0.32
ESR2 Q92731 2/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
KCNN4 O15554 5/20 0.31
CYP2C19 P33261 1/20 0.31
HIF1A Q16665 1/20 0.31
CCNB2 O95067 1/20 0.30
CCNE2 O96020 1/20 0.30
CDK1 P06493 1/20 0.30
CDK4 P11802 1/20 0.30
CCNB1 P14635 1/20 0.30
CCND1 P24385 1/20 0.30
CCNE1 P24864 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL179891 0.78 ALDH1A1 (0.34) MAPK1ALDH1A1ALOX15ESR1ESR2
SCHEMBL28884186 0.78 MAPK1 (0.41) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL21772222 0.74 MAPK1 (0.39) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL21772215 0.74 MAPK1 (0.39) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL27125225 0.74 MAPK1 (0.39) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL2105556 0.73 CYP2C19 (0.44) MAPK1ALDH1A1ALOX15TSHRESR1
SCHEMBL2105418 0.73 MAPK1 (0.38) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL17846812 0.73 MAPK1 (0.38) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL2106794 0.73 TDP1 (0.38) MAPK1ALDH1A1ALOX15TSHRTAAR1
SCHEMBL8847011 0.73 MAPK1 (0.38) MAPK1ALDH1A1ALOX15TSHRTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117178026-A Fluorosilicone release coating composition and release liner 美国陶氏有机硅公司 2023-12-05 CN disclosed
CN-113423571-B Curable silicone composition, release coating agent, release film, and laminate 陶氏东丽株式会社 2023-10-03 CN disclosed
CN-116583403-A Curable silicone composition, release coating agent for silicone adhesive comprising the composition, release film, and laminate 陶氏东丽株式会社 2023-08-11 CN disclosed
CN-116529077-A Curable silicone composition, release coating agent for silicone adhesive comprising the composition, release film, and laminate 陶氏东丽株式会社 2023-08-01 CN disclosed
CN-113453887-B Curable silicone composition, release coating agent formed from the composition, release film using the release coating agent, and laminate 陶氏东丽株式会社 2023-07-18 CN disclosed
CN-113453888-B Curable silicone composition, release coating agent formed from said composition, release film using said release coating agent, and laminate comprising said release film 陶氏东丽株式会社 2023-05-05 CN disclosed