Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554152 | 0.84 | TGFBR1 (0.50) | TGFBR1TGFBR2CTSLHDAC1HDAC3 | |
| SCHEMBL18554366 | 0.81 | CCNE1 (0.48) | TGFBR1CTSLHDAC1HDAC3HDAC2 | |
| SCHEMBL18554274 | 0.78 | TGFBR1 (0.53) | TGFBR1TGFBR2HDAC1HDAC3HDAC2 | |
| SCHEMBL22978902 | 0.78 | ADORA2A (0.46) | CTSLHDAC1HDAC2PDGFRACCNE1 | |
| SCHEMBL29365625 | 0.78 | ADORA2A (0.46) | CTSLHDAC1HDAC2PDGFRACCNE1 | |
| SCHEMBL29366198 | 0.76 | HPGD (0.58) | HTTCTSLHDAC1HDAC3HDAC2 | |
| SCHEMBL18554153 | 0.76 | HPGD (0.58) | HTTCTSLHDAC1HDAC3HDAC2 | |
| SCHEMBL18554142 | 0.76 | TGFBR1 (0.44) | TGFBR1CTSLHDAC1HDAC3HDAC2 | |
| SCHEMBL18554195 | 0.76 | TGFBR1 (0.52) | TGFBR1TGFBR2CTSLHDAC1HDAC3 | |
| SCHEMBL18554354 | 0.75 | BUB1 (0.51) | TGFBR1TGFBR2CTSLHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789681-A | Imidazo pyrimidine compound containing fused ring group, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-112341477-B | Imidazo pyrimidine compound containing fused ring group, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-112341477-A | Imidazo pyrimidine compound containing polycyclic group, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-02-09 | — | — | CN | disclosed |