Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520601 | 0.89 | ABL1 (0.52) | ABL1SRCPOLBCCNA2CDK2 | |
| SCHEMBL29037823 | 0.89 | ABL1 (0.52) | ABL1SRCPOLBCCNA2CDK2 | |
| SCHEMBL29037737 | 0.84 | SRC (0.48) | ABL1SRCPOLBCCNA2CDK2 | |
| SCHEMBL29520459 | 0.84 | SRC (0.48) | ABL1SRCPOLBCCNA2CDK2 | |
| SCHEMBL29037797 | 0.78 | ABL1 (0.45) | ABL1SRCPOLBKMT2ARAB9A | |
| SCHEMBL29520398 | 0.78 | ABL1 (0.45) | ABL1SRCPOLBKMT2ARAB9A | |
| SCHEMBL29037765 | 0.72 | IL2 (0.39) | ABL1SRCPOLBBCRCCNA2 | |
| SCHEMBL29520303 | 0.72 | IL2 (0.39) | ABL1SRCPOLBBCRCCNA2 | |
| SCHEMBL6989383 | 0.72 | KMT2A (0.59) | ABL1SRCPOLBKMT2ARAB9A | |
| SCHEMBL22500906 | 0.71 | ABL1 (0.47) | ABL1BCRCDK2KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |