Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LIG1 | P18858 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037765 | 1.00 | IL2 (0.39) | IL2ALDH1A1L3MBTL1LIG1ABL1 | |
| SCHEMBL29037800 | 0.78 | IL2 (0.40) | IL2L3MBTL1LIG1ABL1SRC | |
| SCHEMBL29037823 | 0.74 | ABL1 (0.52) | ALDH1A1ABL1SRCMEN1KMT2A | |
| SCHEMBL29520601 | 0.74 | ABL1 (0.52) | ALDH1A1ABL1SRCMEN1KMT2A | |
| SCHEMBL29037792 | 0.72 | ABL1 (0.50) | ALDH1A1ABL1SRCMEN1KMT2A | |
| SCHEMBL2061375 | 0.72 | L3MBTL1 (0.43) | ALDH1A1L3MBTL1 | |
| SCHEMBL29037809 | 0.71 | LIG1 (0.47) | IL2ALDH1A1L3MBTL1LIG1MEN1 | |
| SCHEMBL29520459 | 0.70 | SRC (0.48) | ABL1SRCMEN1KMT2ANPC1 | |
| SCHEMBL29037737 | 0.70 | SRC (0.48) | ABL1SRCMEN1KMT2ANPC1 | |
| SCHEMBL15867225 | 0.69 | CYP3A4 (0.49) | IL2ALDH1A1L3MBTL1LIG1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |