Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.64 |
| ▸ | JAK2 | O60674 | 4/20 | 0.60 |
| ▸ | JAK1 | P23458 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 4/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037757 | 0.89 | CDK6 (0.59) | FGFR1JAK2JAK1JAK3EGFR | |
| SCHEMBL29037725 | 0.87 | ALK (0.57) | FGFR1JAK2JAK1JAK3EGFR | |
| SCHEMBL29037770 | 0.86 | FGFR1 (0.58) | FGFR1JAK2JAK1JAK3PTK2 | |
| SCHEMBL29037691 | 0.81 | JAK3 (0.57) | FGFR1JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29037749 | 0.80 | ALK (0.69) | FGFR1EGFRSLC2A1 | |
| SCHEMBL30839225 | 0.80 | TNK2 (0.56) | FGFR1JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29235971 | 0.80 | TNK2 (0.56) | FGFR1JAK2JAK1JAK3LRRK2 | |
| SCHEMBL29037857 | 0.76 | EGFR (0.64) | JAK2JAK1JAK3EGFRTNK2 | |
| SCHEMBL16446555 | 0.76 | JAK2 (1.00) | JAK2JAK1JAK3MAPK8MAPK9 | |
| SCHEMBL23704673 | 0.75 | PKMYT1 (0.69) | JAK3LRRK2PTK2MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |