Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 2/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | CCND1 | P24385 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.57 |
| ▸ | INSR | P06213 | 4/20 | 0.56 |
| ▸ | IGF1R | P08069 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037725 | 0.96 | ALK (0.57) | CDK6CDK4CCND1FGFR1ALK | |
| SCHEMBL29037749 | 0.90 | ALK (0.69) | CDK6FGFR1ALKEGFRLCK | |
| SCHEMBL29037865 | 0.89 | FGFR1 (0.64) | FGFR1INSRIGF1REGFRSLC2A1 | |
| SCHEMBL29037857 | 0.86 | EGFR (0.64) | ALKEGFRJAK2JAK1JAK3 | |
| SCHEMBL29037794 | 0.84 | EGFR (0.65) | FGFR1ALKINSRIGF1REGFR | |
| SCHEMBL29037779 | 0.84 | TNK2 (0.61) | CDK6CDK4CCND1FGFR1ALK | |
| SCHEMBL29037876 | 0.83 | EGFR (0.60) | ALKEGFRJAK2JAK1JAK3 | |
| SCHEMBL29037894 | 0.81 | PAK1 (0.61) | FGFR1ALKEGFRBRD4 | |
| SCHEMBL30965389 | 0.79 | ALK (0.55) | CDK6CDK4CCND1ALKINSR | |
| SCHEMBL29242499 | 0.79 | ALK (0.55) | CDK6CDK4CCND1ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |