Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | WEE1 | P30291 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 10/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037768 | 0.89 | MAPK8 (0.51) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037732 | 0.88 | ALK (0.46) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037694 | 0.88 | ALK (0.46) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037788 | 0.82 | LCK (0.62) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037685 | 0.80 | ALK (0.59) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037854 | 0.78 | EGFR (0.55) | ALKKCNH2FGFR1 | |
| SCHEMBL4503012 | 0.77 | LCK (0.57) | ALKLCKMAPK14WEE1KCNH2 | |
| SCHEMBL29520330 | 0.77 | MAP4K1 (0.59) | ALK | |
| SCHEMBL29037729 | 0.77 | MAP4K1 (0.59) | ALK | |
| SCHEMBL29037855 | 0.77 | LCK (0.59) | ALKLCKMAPK14BRD4MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |