Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 9/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | BMX | P51813 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037788 | 0.92 | LCK (0.62) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037855 | 0.86 | LCK (0.59) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29520500 | 0.85 | SRC (0.58) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037779 | 0.83 | TNK2 (0.61) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037761 | 0.80 | TNK2 (0.50) | LCKMAPK14BRD4MAP3K7MAP2K1 | |
| SCHEMBL29037869 | 0.80 | ALK (0.48) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037688 | 0.80 | LCK (0.70) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL29037768 | 0.80 | MAPK8 (0.51) | ALKLCKMAPK14BRD4MAP3K7 | |
| SCHEMBL4488398 | 0.80 | TNK2 (0.59) | LCKMAPK14BRD4MAP3K7MAP2K1 | |
| SCHEMBL29037767 | 0.80 | SIK1 (0.62) | BRD4TNK2FLT3EGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |