Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 8/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | ROS1 | P08922 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037857 | 0.96 | EGFR (0.64) | EGFRTNK2CSF1RJAK2JAK3 | |
| SCHEMBL29037894 | 0.89 | PAK1 (0.61) | EGFRALK | |
| SCHEMBL29037725 | 0.86 | ALK (0.57) | EGFRTNK2JAK2JAK3ALK | |
| SCHEMBL29037794 | 0.85 | EGFR (0.65) | EGFRJAK2JAK3ALKJAK1 | |
| SCHEMBL29037757 | 0.83 | CDK6 (0.59) | EGFRJAK2JAK3ALKJAK1 | |
| SCHEMBL30444439 | 0.82 | EGFR (0.61) | EGFRALK | |
| SCHEMBL29037756 | 0.82 | EGFR (0.61) | EGFRALK | |
| SCHEMBL29037832 | 0.81 | EGFR (0.51) | EGFRTNK2CSF1RALK | |
| SCHEMBL26875434 | 0.80 | JAK2 (0.65) | EGFRTNK2JAK2JAK3ALK | |
| SCHEMBL29037749 | 0.76 | ALK (0.69) | EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |