Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911937 | 0.89 | CDK1 (0.42) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2904020 | 0.87 | CDK1 (0.41) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2909662 | 0.86 | GSK3A (0.44) | CDK1GSK3AGSK3BSMN1; SMN2KMT2A | |
| SCHEMBL2909439 | 0.86 | CDK1 (0.40) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2911880 | 0.86 | CDK1 (0.40) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2909924 | 0.86 | CDK1 (0.40) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2912739 | 0.86 | CDK1 (0.40) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2913331 | 0.85 | CDK1 (0.41) | CDK1GSK3AGSK3BSMN1; SMN2KMT2A | |
| SCHEMBL2912330 | 0.85 | CDK1 (0.40) | HTTCDK1GSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL2903846 | 0.84 | GSK3A (0.41) | HTTCDK1GSK3AGSK3BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |