SCHEMBL2903864

SCHEMBL2903864

[CH2]C(C)COC(=O)OCCC

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
HSD17B10 Q99714 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35
LMNA P02545 1/20 0.33
TSHR P16473 4/20 0.32
TDP1 Q9NUW8 2/20 0.32
ESR1 P03372 1/20 0.32
CHRM1 P11229 1/20 0.32
SLC6A2 P23975 1/20 0.32
KDR P35968 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.30
SOAT1 P35610 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2901050 0.83 ALDH1A1 (0.59) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL451857 0.83 TSHR (0.43) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL28188062 0.81 HSD17B10 (0.52) ALDH1A1HSD17B10HCAR2LMNATSHR
Ammonia Solution, Strong SCHEMBL27745815 0.81 TSHR (0.42) ALDH1A1HSD17B10HCAR2LMNATSHR
Ethylene SCHEMBL29245194 0.79 ALDH1A1 (0.50) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL5012805 0.79 MAPT (0.43) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL10834976 0.79 ALDH1A1 (0.37) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL10836771 0.79 ALDH1A1 (0.37) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL17057 0.79 ALDH1A1 (0.56) ALDH1A1HSD17B10HCAR2LMNATSHR
SCHEMBL4923499 0.78 TSHR (0.38) ALDH1A1HSD17B10HCAR2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011150380-A1 METHODS OF TREATMENT OF FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS XENOPORT, INC. (US) 2011-12-01 WO claimed
EP-2217564-A1 COMPLEX PANTOIC ACID ESTER NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE XenoPort, Inc. (US) 2010-08-18 EP disclosed
WO-2009033054-A1 COMPLEX PANTOIC ACID ESTER NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE XENOPORT, INC. (US) 2009-03-12 WO disclosed