Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.60 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901444 | 0.79 | NOTUM (0.70) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2898351 | 0.79 | NOTUM (0.70) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3990071 | 0.78 | NOTUM (0.52) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3989189 | 0.77 | NOTUM (0.72) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3981494 | 0.77 | NOTUM (0.72) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL3989172 | 0.76 | HDAC4 (0.54) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2906099 | 0.76 | NOTUM (0.70) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2900978 | 0.76 | NOTUM (1.00) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2123479 | 0.75 | NOTUM (1.00) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2898452 | 0.75 | NOTUM (0.64) | NOTUMCYP2E1CYP2A6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790759-B2 | Glycyrrhetinic acid-30-amide derivatives and their use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2010-09-07 | — | — | US | disclosed |
| EP-1935892-B1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INST PHARM RESEARCH (CN) | 2010-08-11 | — | — | EP | disclosed |
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-09-04 | — | — | US | disclosed |
| EP-1935892-A1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | IL36G, CYP26A1, IL17A | NOTUM 2772/4885CYP2E1 101/4885CYP2A6 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.