IL36G — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ambrisentan (SCHEMBL3679)	0.69	1/20
Ambrisentan (SCHEMBL138157)	0.69	1/20
Ambrisentan (SCHEMBL3023434)	0.69	1/20
Ambrisentan (SCHEMBL20769813)	0.69	1/20
SCHEMBL3023827	0.61	1/20
SCHEMBL3023829	0.61	1/20
SCHEMBL3028683	0.61	1/20
SCHEMBL7933350	0.61	1/20
SCHEMBL2352546	0.58	1/20
SCHEMBL2356501	0.58	1/20
SCHEMBL3025989	0.57	1/20
SCHEMBL3025995	0.57	1/20
SCHEMBL3023738	0.56	1/20
SCHEMBL3030550	0.56	1/20
SCHEMBL15991881	0.56	1/20
SCHEMBL17190123	0.54	1/20
SCHEMBL3714105	0.53	1/20
SCHEMBL3714106	0.53	1/20
SCHEMBL7392841	0.52	1/20
SCHEMBL10316292	0.52	1/20

Clinical trials — most relevant to IL36G by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety Study of PEG-rIL-29 Plus Ribavirin to Treat Chronic Hepatitis C Virus Infection	PHASE2	UNKNOWN
A Study to Evaluate the Efficacy and Safety of Sirukumab in Confirmed Severe or Critical Confirmed Coronavirus Disease (COVID)-19	PHASE2	COMPLETED
Chemoprevention Therapy in Treating Patients at High Risk of Developing Multiple Myeloma	PHASE2	COMPLETED
Study of PEG-rIL-29 (or PEG-IFN Lambda) in Subjects With Chronic Hepatitis C Virus Infection	PHASE1	COMPLETED
Clinical Trial of IL - 22BP Safety, Tolerability, and Antitumor Activity in Refractory Solid Tumors.	PHASE1	RECRUITING
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders	nan	UNKNOWN
The Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia	nan	NOT_YET_RECRUITING
Relation of IL23R and IL17A Gene Polymorphisms Plus Serum Levels of IL23 and IL17A to Rheumatoid Arthritis Susceptibility and Activity	nan	NOT_YET_RECRUITING
GCF and Saliva Levels of IL-36α in Periodontal Disease	nan	COMPLETED
Serum Level of IL31,33 and 36 in Egyptian Paients With Psoriasis	nan	UNKNOWN
Interleukin-38 Levels in Individuals With Periodontitis	nan	UNKNOWN
IL37,Tlymphocytes,NK Cells in Pathogenesis of ITP	nan	UNKNOWN
Cytokine Status of Covid-19 Patients	nan	COMPLETED
Analysis of Gingival Crevicular Fluid	nan	COMPLETED
Initial Management of MRONJ Stages I and II, a Clinical Trial With Detection of Salivary Biomarkers	nan	UNKNOWN
Interleukin-34 Level in Periodontal Disease	nan	UNKNOWN
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient	nan	RECRUITING
T Regulatory Cells in Hepatitis c Infected Patients	nan	COMPLETED
Study on Immune Status of Patients With COVID-19	nan	UNKNOWN
Hemoperfusion With Efferon CT for the Treatment of Patients With Severe Psoriasis	nan	COMPLETED
Chemerin, Fetuin-A, IL-34 and IL-13 Levels in Diabetic Periodontitis Patients	nan	COMPLETED
The Effect of NB-UVB on Interleukin-36 Levels in Psoriasis	nan	UNKNOWN
Analysis of Cytokine Expression Pattern in Systemic Sclerosis	nan	COMPLETED
T Helper Cytokines in End Stage Colorectal Cancers	nan	COMPLETED
Patterns of Early Hepatitis C Virus Decline Predict the Outcome of Interferon Therapy (sIFN-pred2)	nan	UNKNOWN
Effect of Methotrexate on Inflammatory Response in Adult Atopic Dermatitis Patients	nan	COMPLETED
Serum IL 26 as a Marker of Disease Activity in SLE	nan	UNKNOWN
Study to Evaluate the Effect of Botanical Dietary Supplements on Inflammation in Healthy People	nan	COMPLETED
Impact of IL-28B rs12979860 and rs4803217 Gene Polymorphisms Associated With miRNAs Deregulation on HCV-related Hepatocellular Carcinoma	nan	UNKNOWN
Role of Polymorphisms in the IL-1 Gene Cluster	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a IL36G binder may also engage these)

Protein	Name	Similarity
Q866R8	—	0.993	Q866R8 →
O18999	—	0.989	O18999 →
P25085	—	0.989	P25085 →
Q9UHA7	—	0.988	Q9UHA7 →
IL1RN	Interleukin-1 receptor antagonist protein	0.985	landscape →
Q8R460	—	0.983	Q8R460 →
Q29056	—	0.982	Q29056 →
Q9UBH0	—	0.980	Q9UBH0 →
Q9JLA2	—	0.980	Q9JLA2 →
O77482	—	0.980	O77482 →
Q9GMZ4	—	0.980	Q9GMZ4 →
P25086	—	0.979	P25086 →
P26890	—	0.979	P26890 →
Q9QYY1	—	0.977	Q9QYY1 →
Q9BEH0	—	0.972	Q9BEH0 →
Q9D6Z6	—	0.971	Q9D6Z6 →
Q9NZH6	—	0.969	Q9NZH6 →
Q8QFQ8	—	0.965	Q8QFQ8 →
IL18	Interleukin-18	0.963	landscape →
P97636	—	0.963	P97636 →
P70380	—	0.961	P70380 →
Q9XSR0	—	0.961	Q9XSR0 →
Q9TU73	—	0.961	Q9TU73 →
Q9YGD3	—	0.961	Q9YGD3 →
Q95M33	—	0.961	Q95M33 →
Q5I931	—	0.961	Q5I931 →
O19073	—	0.961	O19073 →
Q3ZT29	—	0.960	Q3ZT29 →
Q7Z7L1	—	0.956	Q7Z7L1 →
Q9XSQ7	—	0.954	Q9XSQ7 →