Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11304272 | 0.76 | CYP1B1 (0.48) | CYP1B1CASP3ALDH1A1MAPTUSP2 | |
| SCHEMBL3077626 | 0.74 | PTPN1 (0.46) | ALDH1A1TSHR | |
| SCHEMBL9113894 | 0.73 | MAPT (0.44) | NPSR1CASP3ALDH1A1MAPTHPGD | |
| SCHEMBL1751922 | 0.72 | ALDH1A1 (0.57) | NPSR1ALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL595563 | 0.71 | PLK1 (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL31499095 | 0.71 | PLK1 (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL26837593 | 0.70 | PLK1 (0.40) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL595885 | 0.70 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL10008041 | 0.68 | ALDH1A1 (0.47) | CYP1B1CASP3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19141485 | 0.68 | CA12 (0.50) | CASP3ALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7837981-B2 | Methods for imaging soluble A-beta | GENERAL ELECTRIC COMPANY (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1631561-B1 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GEN ELECTRIC (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7727511-B2 | Agents for imaging soluble a-beta | GENERAL ELECTRIC COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-06-21 | — | — | US | disclosed |
| EP-1631561-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004100998-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | GENERAL ELECTRIC COMPANY | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | APP, APBA1, BACE1 | CYP1B1 4431/4885NPSR1 897/4885CASP3 2416/4885 |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | CYP1B1 4488/4885NPSR1 572/4885CASP3 1637/4885 |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | CYP1B1 4673/4885NPSR1 545/4885CASP3 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.