Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 1.00 |
| ▸ | TOP2B | Q02880 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009336 | 0.88 | TOP2A (0.78) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL11705109 | 0.83 | TRPV1 (0.82) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL13356363 | 0.83 | MAPT (0.80) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL28549583 | 0.79 | CYP1A2 (0.72) | TOP2ATOP2BMAPTHTTGAA | |
| SCHEMBL28551231 | 0.78 | MAPT (0.71) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL29079351 | 0.77 | MAPT (0.68) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL12915848 | 0.77 | MAPT (0.80) | TOP2ATOP2BMAPTHTTTRPV1 | |
| SCHEMBL4530179 | 0.77 | LMNA (0.83) | TOP2ATOP2BMAPTHTTROCK2 | |
| SCHEMBL3061430 | 0.77 | MAPT (1.00) | MAPTHTTGAALMNARAB9A | |
| Hydrochloric Acid SCHEMBL27689202 | 0.75 | MAPT (0.96) | MAPTHTTGAALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260052-B | 2-phenyl naphthalene derivative and preparation method and application thereof | 山东大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-115260052-A | 2-phenylnaphthalene derivative and preparation method and application thereof | 山东大学 | 2022-11-01 | — | — | CN | disclosed |