Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10300785 | 0.89 | KMT2A (0.75) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL13636224 | 0.86 | KMT2A (0.83) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL4384009 | 0.86 | KMT2A (0.83) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2908578 | 0.84 | F2R (0.66) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2903289 | 0.81 | KMT2A (0.71) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2908715 | 0.81 | KMT2A (0.70) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2908215 | 0.81 | F2R (0.74) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2910362 | 0.81 | KMT2A (0.72) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2902111 | 0.78 | ALDH1A1 (0.69) | KMT2AALDH1A1POLBLMNAMEN1 | |
| SCHEMBL2906384 | 0.78 | KMT2A (0.72) | KMT2AALDH1A1POLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041104-B1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR- I ANTAGONISTS | PF MEDICAMENT (FR) | 2010-08-18 | — | — | EP | disclosed |