Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 7/20 | 0.44 |
| ▸ | PYGL | P06737 | 4/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904481 | 1.00 | GPR183 (0.46) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903279 | 0.98 | GPR183 (0.46) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903278 | 0.98 | GPR183 (0.46) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903013 | 0.93 | GPR183 (0.41) | GPR183CCR2PYGL | |
| SCHEMBL2903091 | 0.93 | GPR183 (0.41) | GPR183CCR2PYGL | |
| SCHEMBL2903094 | 0.93 | GPR183 (0.41) | GPR183CCR2PYGL | |
| SCHEMBL2903011 | 0.93 | GPR183 (0.41) | GPR183CCR2PYGL | |
| SCHEMBL2898971 | 0.91 | PYGL (0.42) | GPR183CCR2PYGL | |
| SCHEMBL2898974 | 0.91 | PYGL (0.42) | GPR183CCR2PYGL | |
| SCHEMBL2902783 | 0.91 | GPR183 (0.39) | GPR183NPC1RAB9ATDP1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |