Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714408 | 0.98 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL1941479 | 0.84 | HDAC3 (0.43) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL8681344 | 0.82 | ALDH1A1 (0.38) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL4625651 | 0.81 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL2904519 | 0.80 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL5042302 | 0.80 | IDO1 (0.59) | MEN1ALDH1A1KMT2A | |
| SCHEMBL30785121 | 0.79 | KDM4E (0.53) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL321697 | 0.79 | KDM4E (0.53) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 | |
| SCHEMBL5598123 | 0.78 | TTR (0.54) | MEN1ALDH1A1POLBKMT2AKDM4E | |
| SCHEMBL905352 | 0.78 | TTR (0.51) | SLC6A2SLC6A4SLC6A3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2223916-A1 | Morpholine derivatives as norepinephrine reuptake inhibitors | Eli Lilly and Company (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-1682523-B1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7423037-B2 | e.g. 1-[1,1'-biphenyl]-2-yl-2-morpholin-2-ylpropan-2-ol; antidepressant, anxiolytic agent, cognition activator | ELI LILLY AND COMPANY (US) | 2008-09-09 | — | — | US | disclosed |
| EP-1729754-B1 | SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF HOT FLASHES | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |