Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.82 |
| ▸ | MET | P08581 | 3/20 | 0.82 |
| ▸ | INSR | P06213 | 15/20 | 0.80 |
| ▸ | IGF1R | P08069 | 15/20 | 0.80 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.74 |
| ▸ | AURKA | O14965 | 2/20 | 0.74 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.74 |
| ▸ | JAK2 | O60674 | 2/20 | 0.74 |
| ▸ | STK10 | O94804 | 2/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.74 |
| ▸ | ABL1 | P00519 | 2/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | FYN | P06241 | 2/20 | 0.74 |
| ▸ | FES | P07332 | 2/20 | 0.74 |
| ▸ | CSF1R | P07333 | 2/20 | 0.74 |
| ▸ | YES1 | P07947 | 2/20 | 0.74 |
| ▸ | LYN | P07948 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29045176 | 0.93 | INSR (0.74) | EGFRMETINSRIGF1RALK | |
| SCHEMBL29045195 | 0.90 | INSR (0.71) | EGFRMETINSRIGF1RALK | |
| SCHEMBL22518896 | 0.90 | EGFR (0.87) | EGFRMETINSRIGF1RALK | |
| SCHEMBL21432183 | 0.90 | EGFR (1.00) | EGFRMETINSRIGF1RALK | |
| SCHEMBL31235559 | 0.90 | EGFR (0.80) | EGFRMETINSRIGF1RALK | |
| SCHEMBL26622426 | 0.90 | EGFR (0.80) | EGFRMETINSRIGF1RALK | |
| SCHEMBL23378017 | 0.89 | EGFR (0.88) | EGFRMETINSRIGF1RALK | |
| SCHEMBL21432184 | 0.89 | EGFR (0.79) | EGFRMETINSRIGF1RALK | |
| SCHEMBL15217790 | 0.89 | INSR (1.00) | EGFRMETINSRIGF1RALK | |
| SCHEMBL28368854 | 0.89 | INSR (0.76) | EGFRMETINSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111386266-B | Pyrimidine derivatives having cancer cell growth inhibiting effect and pharmaceutical compositions containing the same | 昂科比克斯有限公司 | 2023-08-04 | — | — | CN | claimed |
| CN-111386266-B | Pyrimidine derivatives having cancer cell growth inhibiting effect and pharmaceutical compositions containing the same | 昂科比克斯有限公司 | 2023-08-04 | — | — | CN | disclosed |