Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXM1 | Q08050 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29045802 | 0.86 | FOXM1 (0.61) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045820 | 0.86 | FOXM1 (0.61) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045837 | 0.86 | FOXM1 (0.70) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045787 | 0.86 | FOXM1 (0.70) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045852 | 0.85 | FOXM1 (0.69) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045860 | 0.84 | FOXM1 (0.67) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL12204203 | 0.83 | FOXM1 (0.49) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045813 | 0.83 | FOXM1 (1.00) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045845 | 0.81 | FOXM1 (0.97) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL29045785 | 0.81 | FOXM1 (0.97) | FOXM1SMN1; SMN2KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304502-B | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-10-18 | — | — | CN | disclosed |
| CN-115304502-A | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-11-08 | — | — | CN | disclosed |