Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.70 |
| ▸ | KDR | P35968 | 9/20 | 0.70 |
| ▸ | BRAF | P15056 | 4/20 | 0.68 |
| ▸ | CDK8 | P49336 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.68 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | CIT | O14578 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | MUSK | O15146 | 1/20 | 0.68 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.68 |
| ▸ | MLNR | O43193 | 1/20 | 0.68 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.68 |
| ▸ | PDE6D | O43924 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462521 | 0.98 | RAF1 (0.73) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL936533 | 0.98 | RAF1 (0.73) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL6030563 | 0.91 | RAF1 (0.64) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL13648125 | 0.89 | RAF1 (0.62) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL5634874 | 0.88 | RAF1 (0.61) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL3711970 | 0.86 | RAF1 (0.77) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL28948534 | 0.86 | RAF1 (0.83) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL104548 | 0.86 | CA7 (0.63) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL13556629 | 0.85 | RAF1 (0.72) | RAF1KDRBRAFCDK8MAPK14 | |
| SCHEMBL16628062 | 0.85 | RAF1 (0.76) | RAF1KDRBRAFCDK8MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114767714-B | Nanometer preparation of alkynyl-modified sorafenib derivative and silver wrapped by pore material, preparation method and application thereof | 济南大学 | 2023-06-20 | — | — | CN | disclosed |