Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.64 |
| ▸ | KDR | P35968 | 8/20 | 0.64 |
| ▸ | CDK8 | P49336 | 3/20 | 0.61 |
| ▸ | BRAF | P15056 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | MUSK | O15146 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | MLNR | O43193 | 1/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | CDK14 | O94921 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462521 | 0.93 | RAF1 (0.73) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL936533 | 0.93 | RAF1 (0.73) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL6030307 | 0.91 | RET (0.63) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL29045853 | 0.91 | RAF1 (0.70) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL5634874 | 0.91 | RAF1 (0.61) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL6031038 | 0.88 | RAF1 (0.67) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL13648125 | 0.86 | RAF1 (0.62) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL4445772 | 0.85 | CDK8 (0.56) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL3539364 | 0.83 | RAF1 (0.74) | RAF1KDRCDK8BRAFMEN1 | |
| SCHEMBL104548 | 0.83 | CA7 (0.63) | RAF1KDRCDK8BRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189665-A1 | Oxamide derivatives useful as raf-kinase inhibitors | MERCK PATENT GMBH (DE) | 2006-08-24 | — | — | US | disclosed |
| EP-1606260-A1 | OXAMIDE DERIVATIVES USEFUL AS RAF-KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004085399-A1 | OXAMIDE DERIVATIVES USEFUL AS RAF-KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189665-A1 | Oxamide derivatives useful as raf-kinase inhibitors | BRAF, RAF1, ARAF | RAF1 2/4885KDR 474/4885CDK8 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.