Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7849764 | 0.96 | MEN1 (0.50) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL27632819 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11218040 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11218041 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL28850573 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL28175660 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL7110698 | 0.87 | — | — | |
| Bicarbonate SCHEMBL7904530 | 0.87 | — | — | |
| Bicarbonate SCHEMBL30212590 | 0.87 | MEN1 (0.50) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL28913475 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8581003-B2 | Process for producing aliphatic carboxylic acid amide | KAO CORPORATION (JP) | 2013-11-12 | — | — | US | disclosed |
| US-20100298604-A1 | PROCESS FOR PRODUCING ALIPHATIC CARBOXYLIC ACID AMIDE | KAO CORPORATION (JP) | 2010-11-25 | — | — | US | disclosed |
| EP-2214815-A1 | PROCESS FOR PRODUCING ALIPHATIC CARBOXYLIC ACID AMIDE | Kao Corporation (JP) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009063813-A1 | PROCESS FOR PRODUCING ALIPHATIC CARBOXYLIC ACID AMIDE | KAO CORPORATION (JP) | 2009-05-22 | — | — | WO | disclosed |