Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 3/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28175660 | 1.00 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL7849764 | 0.96 | MEN1 (0.50) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL11215584 | 0.96 | MEN1 (0.50) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL5133443 | 0.92 | CA4 (0.54) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL11732387 | 0.92 | CA4 (0.54) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL28309302 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL11218040 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL11218041 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL2904779 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B | |
| Bicarbonate SCHEMBL28102608 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA4CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107217301-B | Compound lithium fluoroborate potassium and lithium fluoroborate nonlinear optical crystal of potassium and preparation method and purposes | 中国科学院新疆理化技术研究所 | 2019-04-12 | — | — | CN | disclosed |
| CN-107217301-A | Compound lithium fluoroborate potassium and lithium fluoroborate nonlinear optical crystal of potassium and preparation method and purposes | 中国科学院新疆理化技术研究所 | 2017-09-29 | — | — | CN | disclosed |