Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338929 | 1.00 | RIPK1 (0.58) | RIPK1KMOCHRM4LOXL2JAK2 | |
| SCHEMBL25817019 | 1.00 | RIPK1 (0.58) | RIPK1KMOCHRM4LOXL2JAK2 | |
| SCHEMBL25817123 | 0.86 | RIPK1 (0.58) | RIPK1KMOCHRM4LOXL2KDM4E | |
| SCHEMBL30338755 | 0.86 | RIPK1 (0.54) | RIPK1KMOCHRM4LOXL2JAK2 | |
| SCHEMBL30338930 | 0.86 | RIPK1 (0.58) | RIPK1KMOCHRM4LOXL2KDM4E | |
| SCHEMBL25255204 | 0.86 | RIPK1 (0.54) | RIPK1KMOCHRM4LOXL2JAK2 | |
| SCHEMBL25294372 | 0.86 | RIPK1 (0.54) | RIPK1KMOCHRM4LOXL2JAK2 | |
| SCHEMBL25300836 | 0.85 | RIPK1 (0.58) | RIPK1CHRM4 | |
| SCHEMBL30338736 | 0.85 | RIPK1 (0.58) | RIPK1CHRM4 | |
| SCHEMBL25253223 | 0.85 | RIPK1 (0.58) | RIPK1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | claimed |
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |