Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29048256 | 1.00 | PRMT5 (0.35) | PRMT5WDR77NPSR1MAPTATM | |
| SCHEMBL30547528 | 1.00 | PRMT5 (0.35) | PRMT5WDR77NPSR1MAPTATM | |
| SCHEMBL30339051 | 0.91 | NPSR1 (0.32) | PRMT5WDR77NPSR1MAPTLMNA | |
| SCHEMBL29966722 | 0.87 | RIPK1 (0.38) | NPSR1MAPTGPR119RECQLLMNA | |
| SCHEMBL31205609 | 0.87 | NTRK1 (0.42) | — | |
| SCHEMBL30547551 | 0.87 | USP30 (0.40) | ATMGPR119RECQL | |
| SCHEMBL30339235 | 0.87 | NTRK1 (0.42) | — | |
| SCHEMBL22210859 | 0.87 | RIPK1 (0.38) | NPSR1MAPTGPR119RECQLLMNA | |
| SCHEMBL22608904 | 0.87 | NTRK1 (0.42) | — | |
| SCHEMBL30547522 | 0.87 | USP30 (0.40) | ATMGPR119RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |