Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30525584 | 1.00 | KDM4E (0.42) | KDM4EHCAR2NAPRTCDC7DBF4 | |
| SCHEMBL30525586 | 0.82 | HDAC1 (0.41) | KDM4ECDC7DBF4GLAPIM2 | |
| SCHEMBL29049475 | 0.82 | HDAC1 (0.41) | KDM4ECDC7DBF4GLAPIM2 | |
| SCHEMBL30525582 | 0.79 | KDM4E (0.47) | KDM4EGLADHODHADORA3NPC1 | |
| SCHEMBL2558755 | 0.79 | KDM4E (0.47) | KDM4EGLADHODHADORA3NPC1 | |
| SCHEMBL29049504 | 0.76 | NAPRT (0.43) | KDM4ENAPRTDHODHALDH1A1TSHR | |
| SCHEMBL30525578 | 0.76 | NAPRT (0.43) | KDM4ENAPRTDHODHALDH1A1TSHR | |
| SCHEMBL4527612 | 0.76 | KDM4E (0.45) | KDM4EGLAALDH1A1TSHRKDM4C | |
| SCHEMBL11782992 | 0.75 | MEN1 (0.50) | KDM4ENAPRTCDC7DBF4DHODH | |
| SCHEMBL11782258 | 0.75 | MKNK1 (0.55) | KDM4EHCAR2DHODHALDH1A1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514769-B | 4-hydroxy pyrimidine-5-formylhydrazone derivative, preparation method, pharmaceutical composition and application | 中国药科大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-116514769-A | 4-hydroxy pyrimidine-5-formylhydrazone derivative, preparation method, pharmaceutical composition and application | 中国药科大学 | 2023-08-01 | — | — | CN | disclosed |