Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | TPH1 | P17752 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900072 | 0.92 | BACE1 (0.59) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2903186 | 0.86 | BACE1 (0.58) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2899984 | 0.84 | HDAC8 (0.61) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2899982 | 0.84 | HDAC8 (0.61) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL14381168 | 0.83 | NR1H4 (0.64) | NR1H4TPH1 | |
| SCHEMBL2905576 | 0.83 | HDAC1 (0.52) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2907119 | 0.83 | HDAC1 (0.52) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2909283 | 0.82 | HDAC8 (0.53) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL1109150 | 0.81 | BACE1 (0.47) | HDAC8HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23486555 | 0.80 | SLC7A5 (0.49) | HDAC8BACE1TAAR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763507-B1 | ALPHA-AMINO ACID DERIVATES WITH ANTIINFLAMMATORY ACTIVITY | ITALFARMACO SPA (IT) | 2010-08-11 | — | — | EP | claimed |
| US-7635788-B2 | Alpha-amino acid derivatives with antiinflammatory activity | ITALFARMACO SPA (IT) | 2009-12-22 | — | — | US | claimed |
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | ITALFARMACO SPA (IT) | 2008-03-27 | — | — | US | claimed |
| EP-1763507-B1 | ALPHA-AMINO ACID DERIVATES WITH ANTIINFLAMMATORY ACTIVITY | ITALFARMACO SPA (IT) | 2010-08-11 | — | — | EP | disclosed |
| US-7635788-B2 | Alpha-amino acid derivatives with antiinflammatory activity | ITALFARMACO SPA (IT) | 2009-12-22 | — | — | US | disclosed |
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | ITALFARMACO SPA (IT) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | TNF, NFKBIA, IFNG | HDAC8 4356/4885HDAC1 3360/4885HDAC3 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.