Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.72 |
| ▸ | IKBKB | O14920 | 16/20 | 0.61 |
| ▸ | CHUK | O15111 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1202037 | 0.99 | FYN (0.71) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1203062 | 0.90 | FYN (0.60) | FYNIKBKBCHUKMAPK10NTRK1 | |
| SCHEMBL1202134 | 0.90 | IKBKB (0.65) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1203467 | 0.87 | IKBKB (0.76) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1202618 | 0.87 | FYN (0.61) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1202657 | 0.86 | FYN (0.72) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1202078 | 0.85 | IKBKB (0.60) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL1203005 | 0.84 | IKBKB (0.62) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL30521746 | 0.84 | FYN (1.00) | FYNIKBKBCHUKMAPK10CDK2 | |
| SCHEMBL2941291 | 0.84 | FYN (1.00) | FYNIKBKBCHUKMAPK10CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |