Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203306 | 0.85 | JAK3 (0.49) | JAK3JAK1FYNNTRK1PIM1 | |
| SCHEMBL1202810 | 0.84 | JAK3 (0.49) | JAK3JAK1FYNNTRK1PIM1 | |
| SCHEMBL2902453 | 0.81 | PIM1 (0.61) | FYNMKNK1NTRK1PIM1JAK2 | |
| SCHEMBL1202088 | 0.80 | FYN (0.63) | FYNMKNK1NTRK1PIM1JAK2 | |
| SCHEMBL1203600 | 0.80 | FYN (0.59) | FYNMKNK1NTRK1PIM1 | |
| SCHEMBL1053477 | 0.78 | FYN (0.61) | FYNMKNK1NTRK1PIM1JAK2 | |
| SCHEMBL16331737 | 0.78 | NTRK1 (0.69) | FYNMKNK1NTRK1PIM1JAK2 | |
| SCHEMBL1203378 | 0.77 | NTRK1 (0.56) | FYNMKNK1NTRK1PIM1JAK2 | |
| SCHEMBL1055180 | 0.76 | PIM1 (0.61) | FYNMKNK1NTRK1PIM1 | |
| SCHEMBL2905622 | 0.75 | FYN (0.72) | FYNCDK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |