Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.66 |
| ▸ | MET | P08581 | 3/20 | 0.66 |
| ▸ | INSR | P06213 | 14/20 | 0.64 |
| ▸ | IGF1R | P08069 | 14/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | STK10 | O94804 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | FES | P07332 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29059830 | 0.99 | EGFR (0.65) | EGFRMETINSRIGF1RALK | |
| SCHEMBL29059684 | 0.92 | EGFR (0.62) | EGFRMETINSRIGF1RALK | |
| SCHEMBL25871302 | 0.90 | EGFR (0.66) | EGFRMETINSRIGF1RALK | |
| SCHEMBL26495588 | 0.90 | EGFR (0.82) | EGFRMETINSRIGF1RALK | |
| Hydrochloric Acid SCHEMBL29059662 | 0.90 | EGFR (0.67) | EGFRMETINSRIGF1RALK | |
| Hydrochloric Acid SCHEMBL25262712 | 0.89 | EGFR (0.81) | EGFRMETINSRIGF1RALK | |
| SCHEMBL25870244 | 0.86 | EGFR (0.64) | EGFRMETINSRIGF1RALK | |
| SCHEMBL29059689 | 0.86 | EGFR (0.75) | EGFRMETINSRIGF1RALK | |
| SCHEMBL29059677 | 0.86 | ALK (0.61) | EGFRMETINSRIGF1RALK | |
| SCHEMBL26497572 | 0.86 | EGFR (0.79) | EGFRMETINSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |