Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.61 |
| ▸ | EGFR | P00533 | 8/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 8/20 | 0.60 |
| ▸ | IGF1R | P08069 | 8/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | ROS1 | P08922 | 2/20 | 0.60 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059672 | 0.91 | ALK (0.58) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059813 | 0.90 | ALK (0.65) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059803 | 0.89 | ALK (0.62) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059669 | 0.89 | EGFR (0.62) | ALKEGFRINSRIGF1RZAP70 | |
| SCHEMBL29059767 | 0.89 | ALK (0.61) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL30502332 | 0.87 | ALK (0.60) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059680 | 0.86 | ALK (0.56) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059834 | 0.86 | ALK (0.66) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059696 | 0.86 | EGFR (0.66) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059678 | 0.86 | ALK (0.74) | ALKEGFRINSRIGF1RZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |