Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.66 |
| ▸ | EGFR | P00533 | 6/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059678 | 0.95 | ALK (0.74) | ALKEGFRINSRIGF1RCCNK | |
| SCHEMBL29059689 | 0.93 | EGFR (0.75) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059672 | 0.90 | ALK (0.58) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059680 | 0.88 | ALK (0.56) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059677 | 0.86 | ALK (0.61) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059652 | 0.85 | ALK (0.57) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL29059802 | 0.85 | ALK (0.58) | ALKEGFRMETINSRIGF1R | |
| SCHEMBL25869799 | 0.84 | ALK (0.75) | ALKEGFRINSRIGF1RCCNK | |
| SCHEMBL29059827 | 0.84 | ALK (0.77) | ALKEGFRINSRIGF1RCCNK | |
| SCHEMBL30497488 | 0.84 | ALK (0.74) | ALKEGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |