Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 5/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671886 | 1.00 | ATF4 (0.38) | ATF4PDE4DPRMT5WDR77RECQL | |
| SCHEMBL31495268 | 0.81 | CYP11B1 (0.36) | SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL1813150 | 0.79 | KMT2A (0.39) | ATF4PDE4DPRMT5WDR77PDE4A | |
| SCHEMBL1813151 | 0.79 | KMT2A (0.39) | ATF4PDE4DPRMT5WDR77PDE4A | |
| SCHEMBL29214555 | 0.79 | KMT2A (0.39) | ATF4PDE4DPRMT5WDR77PDE4A | |
| SCHEMBL20722022 | 0.78 | BTK (0.36) | ATF4CYP11B1CYP11B2GAA | |
| SCHEMBL27436810 | 0.78 | EPHX1 (0.37) | CYP11B1CYP11B2GAA | |
| SCHEMBL1118814 | 0.76 | EPHX1 (0.40) | CYP11B1CYP11B2GAA | |
| SCHEMBL16350083 | 0.76 | CYP11B1 (0.34) | CYP11B1CYP11B2 | |
| SCHEMBL5218735 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669738-A | Pyrimidopyridone derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-116568689-A | Polycyclic pyrimidine derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-08 | — | — | CN | disclosed |