Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.39 |
| ▸ | TET3 | O43151 | 2/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28052446 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL3955190 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL11284188 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL6662533 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL247921 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL28954903 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL3647975 | 0.98 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL28954908 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL28954897 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 | |
| Citric Acid SCHEMBL27650526 | 0.98 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CPT2ACLYTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 342 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4030921-B1 | WHEY-BASED NUTRITIONAL COMPOSITIONS FORTIFIED WITH CALCIUM | NESTLE SA (CH) | 2024-02-21 | — | — | EP | claimed |
| CN-115710174-A | Preparation method of high-density citric acid malic acid chelate | 南通励成生物工程有限公司 | 2023-02-24 | — | — | CN | claimed |
| US-11534458-B2 | Phosphorus-sparing nutritional composition | ALBION LABORATORIES, INC. (US) | 2022-12-27 | — | — | US | claimed |
| CN-114946852-A | Citric acid and malic acid powder disinfectant and preparation method thereof | 山东菏泽三仪生物工程有限公司 | 2022-08-30 | — | — | CN | claimed |
| US-20210137975-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2021-05-13 | — | — | US | claimed |
| EP-3817555-A1 | NOVEL COMPOSITION OF SILICA WITH PHENOLIC COMPOUNDS TO ENHANCE YIELDS AND DECREASE BIOTIC AND ABIOTIC STRESSES | Fertis India Pvt. Ltd. (IN) | 2021-05-12 | — | — | EP | claimed |
| CN-111713624-A | Solid beverage and preparation method and application thereof | 同方药业集团有限公司 | 2020-09-29 | — | — | CN | claimed |
| CN-110787132-A | Veterinary disinfectant citric acid and malic acid powder and preparation method thereof | 河南牧翔动物药业有限公司 | 2020-02-14 | — | — | CN | claimed |
| WO-2020008480-A1 | NOVEL COMPOSITION OF SILICA WITH PHENOLIC COMPOUNDS TO ENHANCE YIELDS AND DECREASE BIOTIC AND ABIOTIC STRESSES | FERTIS INDIA PVT. LTD. (IN) | 2020-01-09 | — | — | WO | claimed |
| EP-1755578-B2 | CHEWABLE, SUCKABLE AND SWALLOWABLE TABLET CONTAINING A CALCIUM-CONTAINING COMPOUND AS AN ACTIVE SUBSTANCE | TAKEDA AS (NO) | 2018-11-28 | — | — | EP | claimed |
| WO-2001077044-A1 | AQUEOUS MINERAL COMPOSITIONS AND METHODS FOR THEIR USE | YAMASHITA THOMAS T (US) | 2001-10-18 | — | — | WO | claimed |
| EP-0697877-B1 | PSYLLIUM DRINK MIX COMPOSITIONS | PROCTER & GAMBLE (US) | 2001-09-19 | — | — | EP | claimed |
| EP-1104998-A1 | COMPOSITION | Advanced Nutricional Foods Pty. Limited (AU) | 2001-06-13 | — | — | EP | claimed |
| WO-2000045650-A1 | CALCIUM SUPPLEMENTED FOOD PRODUCTS AND NOVEL CALCIUM-CONTAINING INGREDIENT | NUTRAHEALTH LTD. (UK) (GB) | 2000-08-10 | — | — | WO | claimed |
| WO-2000010402-A1 | COMPOSITION | ADVANCED NUTRITIONAL FOODS PTY. LIMITED (AU) | 2000-03-02 | — | — | WO | claimed |
| EP-0697821-B1 | CHOLESTEROL LOWERING DRINK MIX COMPOSITIONS | PROCTER & GAMBLE (US) | 1998-11-18 | — | — | EP | claimed |
| EP-0542912-A1 | CALCIUM AND TRACE MINERAL SUPPLEMENTS. | PROCTER & GAMBLE (US) | 1993-05-26 | — | — | EP | claimed |
| US-5151274-A | Calcium citrate malate for bone disorders | THE PROCTER & GAMBLE COMPANY (US) | 1992-09-29 | — | — | US | claimed |
| WO-1992002235-A1 | CALCIUM AND TRACE MINERAL SUPPLEMENTS | THE PROCTER & GAMBLE COMPANY (US) | 1992-02-20 | — | — | WO | claimed |
| US-4948799-A | ANTIPSYCHOTIC DRUGS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1990-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11534458-B2 | Phosphorus-sparing nutritional composition | PHPT1, PPA1, PTH1R | ALDH1A1 4773/4885SMN1; SMN2 1232/4885CPT2 813/4885 |
| US-20210137975-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | PHPT1, PPA1, PTH1R | ALDH1A1 4773/4885SMN1; SMN2 1232/4885CPT2 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.