Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 12/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29061645 | 0.91 | DGAT2 (0.56) | DGAT2KMT2AATMNPC1RAB9A | |
| SCHEMBL29511888 | 0.89 | DGAT2 (0.73) | DGAT2KMT2A | |
| SCHEMBL27211590 | 0.89 | DGAT2 (0.73) | DGAT2KMT2A | |
| SCHEMBL27211597 | 0.89 | DGAT2 (0.64) | DGAT2KMT2AATM | |
| SCHEMBL29061644 | 0.89 | DGAT2 (0.62) | DGAT2MAPTPARG | |
| SCHEMBL27211604 | 0.87 | DGAT2 (0.76) | DGAT2KMT2AATM | |
| SCHEMBL27211609 | 0.87 | DGAT2 (0.66) | DGAT2KMT2AATMRORC | |
| SCHEMBL29061634 | 0.87 | DGAT2 (0.65) | DGAT2KMT2AATMNPC1RAB9A | |
| SCHEMBL29512127 | 0.87 | DGAT2 (0.76) | DGAT2KMT2AATM | |
| SCHEMBL29061632 | 0.87 | DGAT2 (0.67) | DGAT2KMT2AATMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116685577-A | Preparation of benzimidazolone derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-09-01 | — | — | CN | claimed |
| CN-116685577-A | Preparation of benzimidazolone derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-09-01 | — | — | CN | disclosed |