SCHEMBL29061982

SCHEMBL29061982

CC[C@@H](C#N)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 4/20 0.43
PDE2A O00408 2/20 0.42
KIF11 P52732 1/20 0.40
ESR1 P03372 4/20 0.37
ESR2 Q92731 4/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
MC4R P32245 1/20 0.36
CTSS P25774 1/20 0.36
CTSK P43235 1/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
CYP19A1 P11511 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL954812 1.00 FFAR1 (0.43) FFAR1PDE2AKIF11ESR1ESR2
SCHEMBL31259082 0.83 FFAR1 (0.42) FFAR1KIF11ESR1ESR2MEN1
SCHEMBL10990831 0.81 FFAR1 (0.40) FFAR1PDE2AKIF11ESR1ESR2
SCHEMBL30564943 0.81 FFAR1 (0.40) FFAR1PDE2AKIF11ESR1ESR2
SCHEMBL28431443 0.81 FFAR1 (0.40) FFAR1PDE2AKIF11ESR1ESR2
SCHEMBL958288 0.80 PNMT (0.47) MEN1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL11160463 0.79 FFAR1 (0.38) FFAR1PDE2AKIF11ESR1ESR2
SCHEMBL953000 0.79 KMT2A (0.46) FFAR1ESR1ESR2MEN1ALDH1A1
SCHEMBL29061981 0.79 KMT2A (0.46) FFAR1ESR1ESR2MEN1ALDH1A1
SCHEMBL28816454 0.78 FFAR1 (0.51) FFAR1PDE2AALDH1A1KMT2ACES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116655482-B Preparation method of gamma-aminobutyric acid derivatives 贵州大学 2024-06-04 CN disclosed
CN-116655482-A Preparation method of gamma-aminobutyric acid derivatives 贵州大学 2023-08-29 CN disclosed