SCHEMBL2906363

SCHEMBL2906363

Cc1cc(C2=NC(C)(C)Cc3c(F)cccc32)cnc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 2/20 0.41
IL2 P60568 3/20 0.34
CYP2A6 P11509 1/20 0.33
STIM1 Q13586 2/20 0.32
ORAI1 Q96D31 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
LMNA P02545 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
APAF1 O14727 1/20 0.32
MITF O75030 1/20 0.32
TDP2 O95551 1/20 0.32
NSD2 O96028 1/20 0.32
MAPT P10636 1/20 0.32
MPI P34949 1/20 0.32
ATM Q13315 1/20 0.32
PDE10A Q9Y233 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2909741 0.87 KDM4E (0.39) ALDH1A1KDM4EIL2STIM1ORAI1
SCHEMBL29369378 0.85 ALDH1A1 (0.41) ALDH1A1KDM4ECYP2A6LMNASMN1; SMN2
SCHEMBL18766109 0.85 ALDH1A1 (0.41) ALDH1A1KDM4ECYP2A6LMNASMN1; SMN2
SCHEMBL4510196 0.84 ALDH1A1 (0.40) ALDH1A1KDM4ESMN1; SMN2ATMGRIN2B
SCHEMBL18766253 0.83 ALDH1A1 (0.39) ALDH1A1KDM4ECYP2A6CYP1A2LMNA
SCHEMBL19994208 0.82 IL2 (0.33) IL2CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL29433011 0.82 ABCB1 (0.37) ALDH1A1KDM4ELMNASMN1; SMN2GRIN2B
SCHEMBL21295278 0.82 ABCB1 (0.37) ALDH1A1KDM4ELMNASMN1; SMN2GRIN2B
SCHEMBL4405493 0.81 AKR1C3 (0.43) ALDH1A1CYP2A6CYP1A2SMN1; SMN2TDP2
SCHEMBL29678248 0.81 AKR1C3 (0.43) ALDH1A1CYP2A6CYP1A2SMN1; SMN2TDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018054721-A1 PYRIDINE COMPOUNDS FOR CONTROLLING PHYTOPATHOGENIC HARMFUL FUNGI BASF SE (DE) 2018-03-29 WO disclosed
WO-2017067784-A1 PYRIDINE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2017-04-27 WO disclosed
EP-2223919-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS AGRICULTURAL AND HORTICULTURAL FUNGICIDES NIPPON SODA CO (JP) 2014-10-15 EP disclosed
EP-2223919-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND BACTERICIDE FOR AGRICULTURAL AND HORTICULTURAL USE Nippon Soda Co., Ltd. (JP) 2010-09-01 EP disclosed