Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 14/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCND2 | P30279 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16453394 | 0.86 | TNK2 (0.73) | SYKTNK2ALKCHEK1JAK2 | |
| SCHEMBL16453383 | 0.82 | TNK2 (0.81) | SYKTNK2ALKCHEK1JAK2 | |
| SCHEMBL26619844 | 0.80 | CCND3 (0.56) | SYKALKJAK2CCND3CCNK | |
| SCHEMBL30670359 | 0.80 | TNK2 (0.59) | SYKTNK2ALKCHEK1JAK2 | |
| SCHEMBL16447810 | 0.80 | TNK2 (0.82) | SYKTNK2ALKCHEK1JAK2 | |
| SCHEMBL26620009 | 0.78 | CCND3 (0.58) | SYKALKJAK2CCND3CCNK | |
| SCHEMBL5092246 | 0.77 | SYK (0.59) | SYKALKJAK2CCND3CCNK | |
| SCHEMBL5098318 | 0.77 | CCND3 (0.58) | SYKALKJAK2CCND3CCNK | |
| SCHEMBL26619987 | 0.76 | CCND3 (0.59) | SYKALKJAK2CCND3CCNK | |
| SCHEMBL5104977 | 0.75 | ALK (0.64) | SYKALKCCND3CCNKCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514779-A | 2, 4-disubstituted-5-fluoropyrimidine derivative and preparation method and application thereof | 中南大学 | 2023-08-01 | — | — | CN | disclosed |