Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 2/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
| ▸ | SYK | P43405 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26619987 | 0.81 | CCND3 (0.59) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619854 | 0.81 | BRD4 (0.47) | ALKSYKBRD4JAK2BTK | |
| SCHEMBL26620009 | 0.80 | CCND3 (0.58) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL29063632 | 0.80 | SYK (0.54) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26620641 | 0.79 | CCND3 (0.56) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL30515504 | 0.78 | SYK (0.48) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL31266515 | 0.76 | JAK2 (0.62) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL5098318 | 0.76 | CCND3 (0.58) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619860 | 0.75 | CCND3 (0.49) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL5104977 | 0.74 | ALK (0.64) | CCND3CCNKCCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213211-A9 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2024-03-21 | — | — | WO | disclosed |
| WO-2023213211-A1 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2023-11-09 | — | — | WO | disclosed |
| CN-116514779-A | 2, 4-disubstituted-5-fluoropyrimidine derivative and preparation method and application thereof | 中南大学 | 2023-08-01 | — | — | CN | disclosed |