Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 14/20 | 0.85 |
| ▸ | CPT1B | Q92523 | 13/20 | 0.85 |
| ▸ | CPT2 | P23786 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837067 | 0.92 | CPT1A (0.84) | CPT1ACPT1BCPT2ALDH1A1LMNA | |
| SCHEMBL2905345 | 0.92 | CPT1A (1.00) | CPT1ACPT1BCPT2 | |
| SCHEMBL2904429 | 0.91 | CPT1A (0.85) | CPT1ACPT1BCPT2ALDH1A1 | |
| SCHEMBL3837062 | 0.91 | CPT1A (0.97) | CPT1ACPT1BCPT2 | |
| SCHEMBL2898313 | 0.89 | CPT1A (0.84) | CPT1ACPT1BCPT2ALDH1A1 | |
| SCHEMBL2903506 | 0.84 | CPT1A (0.84) | CPT1ACPT1BCPT2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3945257 | 0.83 | CPT1A (0.85) | CPT1ACPT1BCPT2 | |
| SCHEMBL2903517 | 0.82 | CPT1A (1.00) | CPT1ACPT1BCPT2 | |
| SCHEMBL2898474 | 0.82 | CPT1A (0.82) | CPT1ACPT1BALDH1A1LMNATSHR | |
| SCHEMBL3945251 | 0.82 | CPT1A (0.96) | CPT1ACPT1BCPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799933-B2 | Sulfonamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-09-21 | — | — | US | disclosed |
| EP-2097373-B1 | SULFONAMIDE DERIVATIVES AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTL ) | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |
| EP-2097373-A1 | SULFONAMIDE DERIVATIVES AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTL ) | F. Hoffmann-Roche AG (CH) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008074692-A1 | SULFONAMIDE DERIVATIVES AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTL ) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |