Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.54 |
| ▸ | CA2 | P00918 | 6/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.54 |
| ▸ | CA3 | P07451 | 3/20 | 0.54 |
| ▸ | CA4 | P22748 | 3/20 | 0.54 |
| ▸ | CA6 | P23280 | 3/20 | 0.54 |
| ▸ | CA5A | P35218 | 3/20 | 0.54 |
| ▸ | CA7 | P43166 | 3/20 | 0.54 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL1839 | 0.91 | CES1 (0.58) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL11048842 | 0.91 | CES1 (0.58) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL29806213 | 0.91 | CES1 (0.58) | CA1CA2PTGS1PTGS2CES1 | |
| Sulfuric Acid SCHEMBL28654341 | 0.91 | CA1 (0.62) | CA1CA2CA12CA9CA14 | |
| P-Nitrophenol SCHEMBL31634024 | 0.89 | CA1 (0.52) | CA1CA2CA12CA9CA14 | |
| P-Nitrophenol SCHEMBL23273098 | 0.88 | CES1 (0.56) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL10883405 | 0.88 | CES1 (0.56) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL2057329 | 0.88 | CA1 (0.58) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL21493265 | 0.88 | CES1 (0.56) | CA1CA2PTGS1PTGS2CES1 | |
| P-Nitrophenol SCHEMBL6760441 | 0.88 | CES1 (0.56) | CA1CA2PTGS1PTGS2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111850092-A | Soil biological activity and productivity evaluation method based on soil enzyme activity determination | 甘肃省地质矿产勘查开发局第三地质矿产勘查院(甘肃遥感地质中心、甘肃地质灾害防治工程勘查设计院、甘肃省地质遗迹评估中心、甘肃省中心实验室) | 2020-10-30 | — | — | CN | claimed |
| US-8771995-B2 | Enzymatic synthesis of sulfated polysaccharides | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2014-07-08 | — | — | US | claimed |
| US-20120322114-A1 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES | RENSSELAER POLYTECHNIC INSTITUTE | 2012-12-20 | — | — | US | claimed |
| US-20090197308-A1 | Enzymatic synthesis of sulfated polysaccharides | RENSSELAER POLYTECHNIC INSTITUTE | 2009-08-06 | — | — | US | claimed |
| US-20090035787-A1 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES WITHOUT IDURONIC ACID RESIDUES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2009-02-05 | — | — | US | claimed |
| WO-2009014715-A2 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES WITHOUT IDURONIC ACID RESIDUES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-01-29 | — | — | WO | claimed |
| EP-1885865-A2 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES | The University of North Carolina at Chapel Hill (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006124801-A2 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-11-23 | — | — | WO | claimed |
| CN-118078847-A | Alopecia preventing composition and preparation method and application thereof | 开远市洁白洗涤用品有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-115678956-A | Method for screening marine bacteria capable of simultaneously producing agarase and arylsulfatase and application | 自然资源部第四海洋研究所(中国—东盟国家海洋科技联合研发中心) | 2023-02-03 | — | — | CN | disclosed |
| CN-112304721-B | Method for preserving sulfate association in urban sewage | 华南理工大学 | 2022-05-24 | — | — | CN | disclosed |
| CN-112082832-B | Method for preserving sulfate combination and glucuronic acid combination in urban sewage | 华南理工大学 | 2022-03-29 | — | — | CN | disclosed |
| CN-112535681-A | Arylsulfatase and glucuronidase inhibitor and preparation method and application thereof | 华南理工大学 | 2021-03-23 | — | — | CN | disclosed |
| CN-112540143-A | Aryl sulfatase inhibitor and preparation method and application thereof | 华南理工大学 | 2021-03-23 | — | — | CN | disclosed |
| US-5268296-A | DNA sequence | CIBA-GEIGY CORPORATION (US) | 1993-12-07 | — | — | US | disclosed |
| US-5114922-A | Animal extracts from leeches | CIBA-GEIGY CORPORATION (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0347376-A2 | Novel polypeptides with an anticoagulant activity | CIBA-GEIGY AG (CH) | 1989-12-20 | — | — | EP | disclosed |
| US-4801576-A | Method of inhibiting blood clotting with desulfatohirudins | CIBA-GEIGY CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| US-4745177-A | ANTICOAGULANTS, POLYPEPTIDES | CIBA-GEIGY CORPORATION (US) | 1988-05-17 | — | — | US | disclosed |
| US-4654302-A | Process for the preparation of desulfatohirudins | CIBA-GEIGY CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |