Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27653716 | 0.92 | GAA (0.53) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL11199799 | 0.89 | MAPT (0.68) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL27847152 | 0.86 | MAPT (0.58) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL117687 | 0.83 | GAA (0.56) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL8313808 | 0.83 | MAPT (0.56) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL29392652 | 0.81 | GAA (0.67) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL112411 | 0.81 | GAA (0.67) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL116789 | 0.80 | MAPT (0.53) | ALDH1A1MAPTPOLBGAALMNA | |
| SCHEMBL9725555 | 0.80 | MAPT (0.56) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL9795841 | 0.79 | KMT2A (0.50) | ALDH1A1MAPTPOLBHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232438-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | The Governors of the University of Alberta (CA) | 2023-08-30 | — | — | EP | disclosed |
| CN-116528867-A | Compounds for the treatment of Alzheimer's disease | 艾伯塔大学理事会 | 2023-08-01 | — | — | CN | disclosed |
| WO-2022082305-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-04-28 | — | — | WO | disclosed |