SCHEMBL29065249

SCHEMBL29065249

O=C(OCC1c2ccccc2-c2ccccc21)C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.51
FABP5 Q01469 3/20 0.50
FABP7 O15540 2/20 0.50
EPHX2 P34913 1/20 0.48
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CASP3 P42574 2/20 0.40
HTR2A P28223 1/20 0.40
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12128707 0.87 KMT2A (0.49) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL24142320 0.86 KMT2A (0.48) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL15463431 0.84 KMT2A (0.49) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL10110895 0.83 KMT2A (0.51) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL29456842 0.83 KMT2A (0.51) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL2605919 0.83 CA1 (0.48) KMT2AFABP5FABP7EPHX2CA1
Trifluoroacetic Acid SCHEMBL7518693 0.83 KMT2A (0.46) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL14035924 0.82 KMT2A (0.45) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL14009338 0.82 KMT2A (0.45) KMT2AFABP5FABP7EPHX2CA1
SCHEMBL515519 0.82 KMT2A (0.50) KMT2AFABP5FABP7EPHX2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12415835-B2 Peptide-compound cyclization method CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-09-16 US disclosed
CN-117750981-A Peptides comprising N-formyl-halomethionine residues and engineered antibody-peptide conjugates thereof 伊莱利利公司 2024-03-22 CN disclosed
US-11891457-B2 Peptide-compound cyclization method CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-02-06 US disclosed
CN-116640182-A Transdermal delivery system for polypeptides and related compounds 泰飞尔生物医药(苏州)有限公司 2023-08-25 CN disclosed
EP-3974563-A1 CYCLIC PEPTIDES Chugai Seiyaku Kabushiki Kaisha (JP) 2022-03-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11891457-B2 Peptide-compound cyclization method VIP, NGLY1, GLP1R KMT2A 4608/4885FABP5 2565/4885FABP7 3166/4885
US-12415835-B2 Peptide-compound cyclization method VIP, NGLY1, GLP1R KMT2A 4608/4885FABP5 2565/4885FABP7 3166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.