Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | GSK3A | P49840 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 11/20 | 0.44 |
| ▸ | CSF1R | P07333 | 5/20 | 0.44 |
| ▸ | FLT1 | P17948 | 5/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | LYN | P07948 | 4/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | BLK | P51451 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | FLT4 | P35916 | 4/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904038 | 0.90 | KDR (0.55) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL2238724 | 0.89 | GSK3B (0.43) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL2239078 | 0.79 | KDR (0.51) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL2238477 | 0.77 | DYRK3 (0.47) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL2905843 | 0.74 | KDR (0.54) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL1703031 | 0.74 | KDR (0.60) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL2239754 | 0.72 | KDR (0.62) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL14270630 | 0.72 | KDR (0.55) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL14700065 | 0.70 | MEN1 (0.65) | GSK3BGSK3ACLK4DYRK3DYRK1A | |
| SCHEMBL3879856 | 0.70 | TEK (0.52) | GSK3BGSK3ACLK4DYRK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845978-B1 | SUBSTITUTED PYRAZOLO-PYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA SA (FR) | 2010-08-18 | — | — | EP | disclosed |
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | DPYD, TYMP, PCK2 | GSK3B 1534/4885GSK3A 1551/4885CLK4 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.