SCHEMBL29065294

SCHEMBL29065294

CC(C)C1(C)COc2c(F)cc(-c3nc(Cl)ncc3Cl)cc21

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 7/20 0.34
CDK6 Q00534 7/20 0.34
CSF1R P07333 2/20 0.34
CCND1 P24385 5/20 0.32
CCND3 P30281 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30557498 1.00 CDK4 (0.34) CDK4CDK6CSF1RCCND1CCND3
SCHEMBL29065292 0.82 CDK4 (0.32) CDK4CDK6CSF1RCCND1CCND3
SCHEMBL30557503 0.82 CDK4 (0.32) CDK4CDK6CSF1RCCND1CCND3
SCHEMBL30557482 0.77 CDK4 (0.59) CDK4CDK6CCND1CCND3
SCHEMBL30557252 0.77 CDK4 (0.59) CDK4CDK6CCND1CCND3
SCHEMBL30557320 0.77 CDK4 (0.59) CDK4CDK6CCND1CCND3
SCHEMBL25782472 0.70 CCND3 (0.33) CDK4CDK6CCND1CCND3
SCHEMBL21245782 0.70 CDK6 (0.61) CDK4CDK6CSF1R
SCHEMBL22650495 0.70 NOTUM (0.38)
SCHEMBL29462387 0.70 NOTUM (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116693510-A Dihydrobenzofuran compound, preparation method and application thereof in medicine 江苏恒瑞医药股份有限公司 2023-09-05 CN disclosed