Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL974640 | 0.98 | THRB (0.57) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL2802555 | 0.98 | THRB (0.57) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL9472725 | 0.98 | THRB (0.57) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL29114833 | 0.95 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL28847790 | 0.95 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL25171144 | 0.93 | THRB (0.53) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL17164482 | 0.93 | THRB (0.53) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Oxalic Acid SCHEMBL7517411 | 0.93 | THRB (0.57) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Bromide SCHEMBL29589655 | 0.93 | — | — | |
| Methacrylic Acid SCHEMBL17360628 | 0.91 | THRB (0.52) | THRBTSHRALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640084-A | Preparation process of (1R, 5S) -6, 6-dimethyl-3-azabicyclo [3.1.0] hexane | 浙江司太立制药股份有限公司 | 2023-08-25 | — | — | CN | claimed |
| CN-116640084-A | Preparation process of (1R, 5S) -6, 6-dimethyl-3-azabicyclo [3.1.0] hexane | 浙江司太立制药股份有限公司 | 2023-08-25 | — | — | CN | disclosed |