Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26186328 | 0.86 | JAK2 (0.55) | ACVRL1JAK2TYK2MAPKAPK2MAPT | |
| SCHEMBL25610860 | 0.86 | JAK2 (0.51) | ACVRL1JAK2TYK2MAPKAPK2MAPT | |
| SCHEMBL19476585 | 0.86 | FLT4 (0.57) | ACVRL1JAK2TYK2MAPKAPK2MAPT | |
| SCHEMBL23588585 | 0.82 | SCN9A (0.57) | ACVRL1JAK2TYK2MAPTMEN1 | |
| SCHEMBL1518963 | 0.81 | MAPK10 (0.59) | ACVRL1JAK2TYK2MAPTRAB9A | |
| SCHEMBL18298629 | 0.80 | ALK (0.53) | ACVRL1JAK2TYK2MAPKAPK2MAPT | |
| SCHEMBL13151491 | 0.80 | MAPK10 (0.62) | MAPTRAB9AMAPK1NPC1CHEK1 | |
| SCHEMBL3871509 | 0.80 | JAK2 (0.52) | JAK2TYK2MAPTMEN1KMT2A | |
| SCHEMBL23588551 | 0.80 | KCNH2 (0.58) | JAK2TYK2MAPTMEN1KMT2A | |
| SCHEMBL5751084 | 0.80 | NOS2 (0.57) | JAK2MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116723839-A | Tricyclic heterobifunctional compounds for degrading target proteins | C4医药公司 | 2023-09-08 | — | — | CN | disclosed |