Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.44 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908039 | 0.80 | MCL1 (0.45) | KDM4EALDH1A1MCL1SCN9AP2RY12 | |
| SCHEMBL1111239 | 0.78 | P2RY12 (0.52) | MCL1P2RY12 | |
| SCHEMBL2899930 | 0.77 | MCL1 (0.52) | KDM4EALDH1A1MCL1 | |
| SCHEMBL4271936 | 0.77 | NPC1 (0.55) | KDM4EALDH1A1SMN1; SMN2MCL1P2RY12 | |
| SCHEMBL12923382 | 0.77 | MAPT (0.43) | KDM4EALDH1A1 | |
| SCHEMBL4262285 | 0.76 | MCL1 (0.49) | MCL1P2RY12 | |
| Hydrochloric Acid SCHEMBL986304 | 0.76 | MAPT (0.43) | KDM4EALDH1A1 | |
| SCHEMBL4259792 | 0.74 | RARB (0.53) | MCL1P2RY12 | |
| SCHEMBL4265711 | 0.73 | MCL1 (0.74) | MCL1P2RY12 | |
| SCHEMBL1111184 | 0.72 | MCL1 (0.64) | KDM4EALDH1A1SMN1; SMN2MCL1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |