Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1111239 | 0.88 | P2RY12 (0.52) | MCL1P2RY12 | |
| SCHEMBL2906647 | 0.80 | KDM4E (0.49) | MCL1P2RY12SCN9AKDM4EALDH1A1 | |
| SCHEMBL2899930 | 0.79 | MCL1 (0.52) | MCL1KDM4EALDH1A1 | |
| SCHEMBL4271936 | 0.79 | NPC1 (0.55) | MCL1P2RY12KDM4EALDH1A1 | |
| SCHEMBL4262285 | 0.78 | MCL1 (0.49) | MCL1P2RY12 | |
| SCHEMBL1111184 | 0.77 | MCL1 (0.64) | MCL1SCN9AKDM4EALDH1A1 | |
| SCHEMBL984203 | 0.76 | MAPT (0.46) | KDM4EALDH1A1 | |
| SCHEMBL4259792 | 0.75 | RARB (0.53) | MCL1P2RY12 | |
| SCHEMBL4265711 | 0.75 | MCL1 (0.74) | MCL1P2RY12 | |
| SCHEMBL15416881 | 0.72 | LSS (0.63) | FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |